Garvey 2012.

Methods	Study design: Randomized controlled trial Setting: Smoking cessation research clinic, Boston USA Recruitment: Community volunteers, motivated to quit
Participants	278 smokers of ≥ 5 cpd. 53% women, av. age 47, av. cpd 18
Interventions	Therapist: MA or BA in psychology, 3 full days training Both group received nicotine patches for 12 weeks, dose tailored to baseline smoking 1. Front‐loaded CBT‐based counselling; 2 pre‐quit and 12 post‐quit, 6 post‐quit sessions received in first 2 weeks. Pre‐quit sessions approx. 45 mins each, post‐quit 20 ‐ 30 mins. Last 3 sessions at 6 m, 9 m, 12 m 2. Weekly counselling. Same number and duration of sessions, but weekly to 12 wks
Outcomes	Continuous abstinence from quit date at 12 m, (never smoking for 7+ consecutive days nor for 7+ consecutive episodes and PP also reported) Validation: CO < 8 ppm
Notes	New for 2016 update Analysis 3, not pooled with other studies. Authors report significantly lower likelihood of relapse, using hazard ratio and continuous abstinence to define relapse. Risk ratio based on 11.7% versus 6.3% abstinent at 12 m is not significant
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Block randomization, method of sequence generation not described
Allocation concealment (selection bias)	Unclear risk	"randomization occurred at the end of the baseline visit following the consenting process and administration of baseline measures" but no additional information
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemical validation of abstinence
Incomplete outcome data (attrition bias) All outcomes	Low risk	20 (14%) front‐loaded and 16 (11.5%) weekly did not start or dropped out before quit date. Not included in denominators for MA. Later losses treated as smokers