Hennrikus 2010.

Methods	Study design: Randomized controlled trial Setting: 2 medical centres; USA Recruitment: probable smokers with lower extremity PAD
Participants	687 current smokers with PAD; 15% women, av. age 60, av. cpd 18
Interventions	Therapists: smoking cessation counsellor 1. Verbal advice to quit from vascular provider 2. Letter from vascular provider + intensive counselling, at least 6 sessions over 5 m, first in person then phone. Information about pharmacotherapies but not provided
Outcomes	Abstinence at 6 m (PP) Validation: saliva cotinine < 10 ng/ml, or CO < 8 ppm for people using NRT
Notes	New for 2016 update High use of pharmacotherapies in both groups; 87% in I, 67% in C
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"predetermined block randomization schedule stratified by medical center"
Allocation concealment (selection bias)	Unclear risk	No details given
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemical validation of abstinence
Incomplete outcome data (attrition bias) All outcomes	Low risk	25% I, 17% C lost at 6 m. 4 deaths (3I, 1C) excluded from MA denominators