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. 2017 Mar 31;2017(3):CD001292. doi: 10.1002/14651858.CD001292.pub3

McCarthy 2008.

Methods Study design: Randomized controlled trial
Setting: Clinic, USA
 Recruitment: community volunteers
Participants 463 smokers
 50% women, av. age 36 ‐ 41 across arms, av. cpd 22
Interventions Therapists: trained college‐aged or bachelor's level staff, supervised by experienced counsellor
Factorial trial. Bupropion/placebo pharmacotherapy arms collapsed
 1. Counselling; 8 x 10‐min sessions, 2 prequit, TQD, 5 over 4 wks
 2. Psychoeducation about medication, support and encouragement. Same no. of sessions, 80 mins less contact time
Outcomes 7‐day PP abstinence at 12 m
 Validation: CO ≤ 10 ppm
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Random number table
Allocation concealment (selection bias) Low risk Staff who screened and enrolled participants were unaware of the experimental condition to be assigned
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Biochemical validation of abstinence
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 171 (37%) failed to attend quit date visit or lost to follow‐up, included in ITT analysis