McCarthy 2008.
Methods | Study design: Randomized controlled trial Setting: Clinic, USA Recruitment: community volunteers |
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Participants | 463 smokers 50% women, av. age 36 ‐ 41 across arms, av. cpd 22 | |
Interventions | Therapists: trained college‐aged or bachelor's level staff, supervised by experienced counsellor Factorial trial. Bupropion/placebo pharmacotherapy arms collapsed 1. Counselling; 8 x 10‐min sessions, 2 prequit, TQD, 5 over 4 wks 2. Psychoeducation about medication, support and encouragement. Same no. of sessions, 80 mins less contact time |
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Outcomes | 7‐day PP abstinence at 12 m Validation: CO ≤ 10 ppm | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Random number table |
Allocation concealment (selection bias) | Low risk | Staff who screened and enrolled participants were unaware of the experimental condition to be assigned |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Biochemical validation of abstinence |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 171 (37%) failed to attend quit date visit or lost to follow‐up, included in ITT analysis |