2. Indirect comparisons of the diagnostic accuracy of the six most evaluated test strategies.
|
Ratio of DORs (95% CI); P value |
1T PAPP‐A, 2T total hCG, 2T uE3 and 2T AFP | 1T PAPP‐A, 2T total hCG, 2T uE3, 2T AFP and 2T Inhibin A | 1T NT, 2T total hCG and 2T AFP | 1T NT, 2T total hCG, 2T uE3 and 2T AFP | 1T NT, 1T PAPP‐A, 2T free ßhCG, 2T uE3, 2T AFP and 2T Inhibin A | |
|
DOR (95% CI) Studies |
96 (48, 190) K =4 |
114 (62, 210) K = 3 |
103 (49, 215) K = 4 |
109 (51, 233) K = 4 |
214 (125, 367) K = 4 |
|
| 1T PAPP‐A, 2T total hCG, 2T uE3, 2T AFP and 2T Inhibin A | 114 (62, 210) K = 3 |
1.19 (0.61, 2.32); P = 0.58 | ||||
| 1T NT, 2T total hCG and 2T AFP | 103 (49, 215) K = 4 |
1.08 (0.51, 2.36); P = 0.83 | 0.91 (0.43, 1.90); P = 0.78 | |||
| 1T NT, 2T total hCG, 2T uE3 and 2T AFP | 109 (51, 233) K = 4 |
1.14 (0.54, 2.42); P = 0.71 | 0.96 (0.45, 2.03); P = 0.90 | 1.06 (0.47, 2.41); P = 0.88 |
||
| 1T NT, 1T PAPP‐A, 2T free ßhCG, 2T uE3, 2T AFP and 2T Inhibin A | 214 (125, 367) K = 4 |
2.24 (1.00, 5.00); P = 0.049 | 1.88 (0.88, 3.99); P = 0.094 | 2.08 (0.89, 4.87); P = 0.09 |
1.96 (0.82, 4.67); P = 0.12 |
|
| 1T NT, 1T PAPP‐A, 2T total hCG, 2T uE3, 2T AFP and 2T Inhibin A | 339 (163, 705) K = 3 |
3.55 (1.28, 9.89); P = 0.019 | 2.98 (1.14; 7.80); P = 0.029 | 3.29 (1.15, 9.47); P = 0.030 |
3.11 (1.07, 9.07); P = 0.039 |
1.58 (0.64, 3.95); P = 0.30 |
Indirect comparisons were made using all available data. Ratio of diagnostic odds ratios (DORs) were computed by division of the DOR for the test in the row by the DOR for the test in the column. If the ratio of DORs is greater than one, then the diagnostic accuracy of the test in the row is higher than that of the test in the column; if the ratio is less than one, the diagnostic accuracy of the test in the column is higher than that of the test in the row. All test combinations include maternal age.
1T = first trimester; 2T = second trimester; K = number of studies; CI ‐ confidence interval.
AFP = alpha‐fetoprotein; ßhCG = beta human chorionic gonadotrophin; FPR = false positive rate; hCG = human chorionic gonadotrophin; NT = nuchal translucency; PAPP‐A = pregnancy‐associated plasma protein‐A; uE3 = unconjugated oestriol.