Rodrigues 2009.
| Clinical features and settings | Routine screening | |
| Participants | 3299 participants: 2290 undergoing integrated and 1009 undergoing serum integrated screening Portugal ‐ screening programme March 2003 ‐ August 2007 Pregnant women Median maternal age: integrated screening 30.6 years, serum integrated screening 30.9 years First and second trimester |
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| Study design | Retrospective cohort | |
| Target condition and reference standard(s) | Down's syndrome: 14 cases (integrated screening 8, serum integrated screening 6) Reference standards: karyotyping or follow‐up to birth |
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| Index and comparator tests | Maternal age First trimester NT (details not reported) First trimester PAPP‐A and second trimester free ßhCG and AFP (TRACE technology, Brahms Kryptor Systems) Risk cut‐point 1:300 for integrated and serum integrated screening |
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| Follow‐up | Detail of follow‐up not reported | |
| Aim of study | To report an audit of an integrated and serum integrated screening programme | |
| Test characteristics | ||
| Reference standard used | ||
| Notes | ||
| Table of Methodological Quality | ||
| Item | Authors' judgement | Description |
| Representative spectrum? All tests | Yes | Routine screening of typical pregnant population |
| Acceptable reference standard? All tests | Yes | Karyotyping or follow‐up to birth |
| Partial verification avoided? All tests | Unclear | Unclear if all women received a reference standard |
| Differential verification avoided? All tests | No | Choice of reference standard depended on index test results |
| Incorporation avoided? All tests | Yes | Reference standard was independent of the index test |
| Reference standard results blinded? All tests | No | Reference standard interpreted with knowledge of index test results |
| Index test results blinded? All tests | Yes | Index test interpreted without knowledge of reference standard results |
| Relevant clinical information? All tests | Yes | Information available as would be in standard clinical practice |
| Uninterpretable results reported? All tests | No | No details given for test failures/uninterpretable measurements |
| Withdrawals explained? All tests | No | No details of withdrawals given |