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. 2017 Mar 7;2017(3):CD011314. doi: 10.1002/14651858.CD011314.pub2

Xiao 2008.

Methods Randomised clinical trial with 2 arms: three dimensional conformal radiotherapy (3‐DCRT) plus transarterial chemoembolisation (TACE) versus TACE. Parallel‐group design
Participants 60 people with unresectable primary hepatic carcinoma. TACE + 3‐DCRT = 30; TACE = 30
Median age: not reported
Male/female: 45/15
Recruitment: January 2002 to June 2006
Inclusion criteria:
Chinese Medical Association guideline:
  • KPS ≥ 70

  • Child‐Pugh class A or B

  • I‐IIIa with no liver cancer metastasis

Interventions TACE: femoral artery by Seldinger technique
3‐DCRT: total average dose = 55 Gy
Outcomes
  1. Short‐term effects

  2. Survival rate

  3. Toxic and side effects

Notes Country of the study: China
We were unable to make a contact with the corresponding author to request missing data.
Funding: unclear
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Allocation sequence was generated by random table number.
Allocation concealment (selection bias) Unclear risk The method used to conceal the allocation was not described.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk The trial was not blinded, so that the allocation was known during the trial.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Outcome was assessed by apparatus.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk There were insufficient data to assess attrition bias.
Selective reporting (reporting bias) High risk The study did not report cancer‐related mortality, quality of life, or serious adverse events.
For profit bias Unclear risk Unclear funding source.
Other bias Unclear risk Unclear risk of other bias.