3. Included or excluded studies and Cochrane reviews.

Study tag	Participants ‐ people with schizophrenia					Relevant Cochrane reviews
	+ additional problems	‐ not specifically aggressive/agitated		‐ aggressive/agitated
		Comparison		Comparison
		Intervention #1	Intervention #2	Intervention #1	Intervention #2
Baldacara 2011	+ none specified	Not applicable		Haloperidol	Haloperidol + midazolam	Gillies 2013; Powney 2012
					Olanzapine	Powney 2012
					Ziprasidone	Powney 2012
Hou 2011					Risperidone + lorazepam	Gillies 2013; Powney 2012
Baldacara 2011, Mantovani 2013				Haloperidol + midazolam	Olanzapine	Gillies 2013; Powney 2012
					Ziprasidone	Gillies 2013; Powney 2012
Srinath 2010				Haloperidol + promethazine	Lorazepam	Gillies 2013; Powney 2012
Baldacara 2011, Mantovani 2013				Olanzapine	Ziprasidone	Belgamwar 2005
Levin 1959		Chlorpromazine	Phenobarbital	Not applicable		‐
			Placebo			Adams 2014
			Promethazine			‐
Bender 2003		Perazine	Trimipramine			‐
Levin 1959		Phenobarbital	Placebo			‐
		Promethazine	Phenobarbital			‐
			Placebo			‐
Merlo 2002		Risperidone (2 mg)	Risperidone (4 mg)			Li 2009
Brannen 1969		Trifluoperazine	Placebo			Koch 2014
St. Jean 1967	+ “mental deficiency" [? learning disability]	Chlorpromazine	Periciazine			‐
Yagi 1973	+ drug‐induced parkinsonism/EPS	Mazaticol hydrochloride	Promethazine			‐
			Trihexyphenidyl			‐
Otsuka 1978		Methixene	Promethazine			‐
			Trihexyphenidyl			‐
Itoh 1972		Piroheptine	Promethazine			‐
			Trihexyphenidyl			‐
Perenyi 1989		Procyclidine	Promethazine			Essali 2013
St. Jean 1964		Promethazine	Placebo			‐
Otsuka 1978, Itoh 1972, Yagi 1973	+ drug‐induced parkinsonism/EPS	Promethazine	Trihexyphenidyl			‐
Claveria 1975	+ tardive dyskinesia	Pimozide	Placebo			Mothi 2013
Yang 1999		Promethazine				‐

EPS: extrapyramidal symptoms