7. Studies with a gingival bleeding outcome not included in meta‐analyses.

Time	Study ID	Comparison	Index	CHX mean (SD)	Control mean (SD)	Total n	Notes
4 to 6 weeks	Axelsson 1987	CHX 0.2% vs CHX 0.1% vs placebo	Mean % of gingival units with GI score 2 or 3	12%/11%	25%	64	Did not report a SD. Quote: "In all…study groups, the % of gingival units scored GI 2+3 was reduced between baseline..and end of trial"
	Graziani 2015	CHX 0.2%+Alc vs CHX 0.2% no Alc vs CHX+ADS vs control rinse	FMBS /BOP	Not clear	13.47%	70	Partial reporting of outcome data. Quote: "Statistically significant decreases in mean full‐mouth scores of gingival inflammation were noted for all experimental study groups at day 35 compared to baseline. Between‐group changes in FMBS…were statistically significant only when CHX2 (mean difference of 43.4 ± 22.4, P = 0.05) and CHX 3 (mean difference of 46.1 ± 23.1, P = 0.05) were compared to the CTRL group" (note: CHX 2 = CHX no Alc, CHX 3 = CHX + ADS)
	Sanz 1989	CHX 0.12% vs placebo	Mean % sites GI score 2 and 3	18.78%	31.31%	38	Did not report a SD. Quote: "Beginning at 4 weeks of rinsing, gingival bleeding was significantly lower in the CHX group compared to the placebo group by an average of 41.6% (P < 0.05). At 6 weeks that reduction was 40%, (P < 0.05)"
7 to 12 weeks	Corbet 1997	CHX 0.12% vs placebo	Mean % sites GI score 2 and 3	27%(anterior) 42%(posterior)	52%(anterior) 75%(posterior)	36	Did not report a SD. Quote: "The difference between the mean percentage of GB of the test and control groups at 3 months was highly significant (P < 0.001)"
	Segreto 1986	CHX 0.2% vs CHX 0.12% vs placebo	Mean % sites GI score 2 and 3	Examiner A: 3.4%/2% Examiner B: 7.2%/6.2%	Examiner A: 3.81% Examiner B: 14.9%	454	Did not report a SD. O.2% Quote: "Bleeding was 31% lower (range 11‐52%) compared to the placebo group" (P > 0.05) 0.12% Quote: "..gingival bleeding was significantly lower by an average of 53% for both examiners (range 48‐59%)" (P ≤ 0.05)
6 months	Banting 1989	CHX 0.12% vs placebo	Mean % sites GI score 2 and 3	2.41%	4.12%	383	Did not report a SD. Regarding outcomes at 6 months to 2 years: Quote: "Subjects in the treatment group…displayed between 42% and 51% fewer sites with moderate to severe gingivitis (GI scores of 2 or 3) compared with subjects in the control group" (P < 0.0001)
	Charles 2004	CHX 0.12% vs control	Mean % sites GI score 2 and 3	11.01%	20.65%	1156 sites	% of bleeding sites in each group is presented. There is a unit of analysis error (number of sites rather than number of subjects). Quote: "There was a considerable reduction in percent bleeding sites in the chlorhexidine…groups at 6 months compared with both control and baseline"
	Lucas 1999	CHX 0.12% vs placebo	Mean % sites GI score 2 and 3	1%	4.2%	20	Did not report a SD. Quote: "Although the percentage of bleeding surfaces in the chlorhexidine group was less than in the placebo group on days 90 (33%) and 180 (76%), the differences were not significant" (P = 0.07)
	Sanz 1994	CHX 0.12% vs placebo	% sites GI score 2 and 3	Graph	Graph	130	% bleeding sites reported incompletely in text and also in a graph. Did not report a SD. Quote: "At 6 months…the positive control group had significantly fewer bleeding sites than the control group (.. 23%...)"
Gingival bleeding > 6 months	Banting 1989	CHX 0.12% vs placebo	Mean % sites GI score 2 and 3	4.41%	8.88%	272	Did not report a SD. Regarding outcomes at 6 months to 2 years: Quote: "Subjects in the treatment group…displayed between 42% and 51% fewer sites with moderate to severe gingivitis (GI scores of 2 or 3) compared with subjects in the control group" (P < 0.0001)

ADS = antidiscolouration system; Alc = alcohol; BOP = bleeding on probing; CHX = chlorhexidine; FMBS = Full‐Mouth Bleeding Score; GI = Gingival Index; SD = standard deviation.

Total n is the number of participants analysed in the study arms relevant to the review.