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. 2017 Mar 28;2017(3):CD011650. doi: 10.1002/14651858.CD011650.pub2

Comparison 2. Non‐surgical interventions.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Mortality at maximal follow‐up 10   Hazard Ratio (IV, Fixed, 95% CI) Subtotals only
2.1.1 Laser versus radiofrequency ablation 1 140 Hazard Ratio (IV, Fixed, 95% CI) 1.77 [0.85, 3.68]
2.1.2 Percutaneous acetic acid injection versus radiofrequency ablation 1 125 Hazard Ratio (IV, Fixed, 95% CI) 1.77 [1.12, 2.79]
2.1.3 Percutaneous alcohol injection versus radiofrequency ablation 5 882 Hazard Ratio (IV, Fixed, 95% CI) 1.49 [1.18, 1.88]
2.1.4 Radiofrequency ablation plus percutaneous alcohol injection versus radiofrequency ablation 1 86 Hazard Ratio (IV, Fixed, 95% CI) 0.66 [0.41, 1.06]
2.1.5 Transarterial chemoembolisation plus radiofrequency ablation versus radiofrequency ablation 1 44 Hazard Ratio (IV, Fixed, 95% CI) 1.12 [0.48, 2.58]
2.1.6 Percutaneous alcohol injection versus percutaneous acetic acid injection 1 125 Hazard Ratio (IV, Fixed, 95% CI) 1.15 [0.79, 1.65]
2.1.7 Transarterial chemoembolisation plus percutaneous alcohol injection versus percutaneous alcohol injection 2 202 Hazard Ratio (IV, Fixed, 95% CI) 0.81 [0.65, 1.01]
2.2 Cancer‐related mortality at maximal follow‐up 5   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.2.1 Laser versus radiofrequency ablation 1 140 Odds Ratio (M‐H, Fixed, 95% CI) 1.26 [0.49, 3.27]
2.2.2 Percutaneous acetic acid injection versus radiofrequency ablation 1 125 Odds Ratio (M‐H, Fixed, 95% CI) 2.42 [0.70, 8.31]
2.2.3 Percutaneous alcohol injection versus radiofrequency ablation 3 458 Odds Ratio (M‐H, Fixed, 95% CI) 2.18 [1.22, 3.89]
2.2.4 Percutaneous alcohol injection versus percutaneous acetic acid injection 1 125 Odds Ratio (M‐H, Fixed, 95% CI) 1.15 [0.43, 3.07]
2.2.5 Transarterial chemoembolisation plus percutaneous alcohol injection versus percutaneous alcohol injection 1 52 Odds Ratio (M‐H, Fixed, 95% CI) 0.07 [0.00, 1.41]
2.3 Mortality (> 1 year) 6   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.3.1 Laser versus radiofrequency ablation 1 140 Odds Ratio (M‐H, Fixed, 95% CI) 1.51 [0.73, 3.12]
2.3.2 Percutaneous acetic acid injection versus radiofrequency ablation 1 124 Odds Ratio (M‐H, Fixed, 95% CI) 1.96 [0.82, 4.72]
2.3.3 Percutaneous alcohol injection versus radiofrequency ablation 4 598 Odds Ratio (M‐H, Fixed, 95% CI) 1.69 [1.15, 2.49]
2.3.4 Percutaneous alcohol injection versus percutaneous acetic acid injection 1 125 Odds Ratio (M‐H, Fixed, 95% CI) 1.21 [0.54, 2.70]
2.3.5 Transarterial chemoembolisation plus percutaneous alcohol injection versus percutaneous alcohol injection 1 52 Odds Ratio (M‐H, Fixed, 95% CI) 0.41 [0.11, 1.58]
2.4 Serious adverse events (number of participants) 11   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.4.1 Laser versus radiofrequency ablation 2 170 Odds Ratio (M‐H, Fixed, 95% CI) 1.00 [0.06, 16.31]
2.4.2 Microwave ablation versus radiofrequency ablation 1 72 Odds Ratio (M‐H, Fixed, 95% CI) 4.38 [0.46, 41.22]
2.4.3 Percutaneous acetic acid injection versus radiofrequency ablation 1 125 Odds Ratio (M‐H, Fixed, 95% CI) 0.13 [0.01, 2.65]
2.4.4 Percutaneous alcohol injection versus radiofrequency ablation 3 365 Odds Ratio (M‐H, Fixed, 95% CI) 0.67 [0.19, 2.40]
2.4.5 Radiofrequency ablation plus chemotherapy versus radiofrequency ablation 1 27 Odds Ratio (M‐H, Fixed, 95% CI) Not estimable
2.4.6 Radiofrequency ablation plus percutaneous alcohol injection versus radiofrequency ablation 1 86 Odds Ratio (M‐H, Fixed, 95% CI) Not estimable
2.4.7 Transarterial chemoembolisation plus radiofrequency ablation versus radiofrequency ablation 2 84 Odds Ratio (M‐H, Fixed, 95% CI) 2.11 [0.18, 25.35]
2.4.8 Percutaneous alcohol injection versus percutaneous acetic acid injection 1 125 Odds Ratio (M‐H, Fixed, 95% CI) Not estimable
2.4.9 Transarterial chemoembolisation plus percutaneous alcohol injection versus percutaneous alcohol injection 1 52 Odds Ratio (M‐H, Fixed, 95% CI) 5.41 [0.25, 118.34]
2.5 Serious adverse events (number of events) 2   Rate Ratio (IV, Fixed, 95% CI) Totals not selected
2.5.1 Percutaneous alcohol injection versus radiofrequency ablation 1   Rate Ratio (IV, Fixed, 95% CI) Totals not selected
2.5.2 Transarterial chemoembolisation plus radiofrequency ablation versus radiofrequency ablation 1   Rate Ratio (IV, Fixed, 95% CI) Totals not selected
2.6 Any adverse events (number of participants) 3   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.6.1 Percutaneous acetic acid injection versus radiofrequency ablation 1 125 Odds Ratio (M‐H, Fixed, 95% CI) 0.39 [0.10, 1.59]
2.6.2 Percutaneous alcohol injection versus radiofrequency ablation 3 548 Odds Ratio (M‐H, Fixed, 95% CI) 0.88 [0.43, 1.81]
2.6.3 Percutaneous alcohol injection versus percutaneous acetic acid injection 1 125 Odds Ratio (M‐H, Fixed, 95% CI) 0.33 [0.03, 3.24]
2.7 Any adverse events (number of events) 6   Rate Ratio (IV, Fixed, 95% CI) Subtotals only
2.7.1 Laser versus radiofrequency ablation 2 170 Rate Ratio (IV, Fixed, 95% CI) 0.83 [0.57, 1.20]
2.7.2 Percutaneous alcohol injection versus radiofrequency ablation 2 334 Rate Ratio (IV, Fixed, 95% CI) 0.90 [0.71, 1.14]
2.7.3 Transarterial chemoembolisation plus radiofrequency ablation versus radiofrequency ablation 1 40 Rate Ratio (IV, Fixed, 95% CI) 1.30 [0.78, 2.14]
2.7.4 Transarterial chemoembolisation plus percutaneous alcohol injection versus percutaneous alcohol injection 1 52 Rate Ratio (IV, Fixed, 95% CI) 0.53 [0.42, 0.67]
2.8 HCC recurrence (local or distal) 3   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.8.1 Laser versus radiofrequency ablation 1 140 Odds Ratio (M‐H, Fixed, 95% CI) 0.88 [0.44, 1.76]
2.8.2 Percutaneous alcohol injection versus radiofrequency ablation 2 371 Odds Ratio (M‐H, Fixed, 95% CI) 1.58 [1.02, 2.45]
2.9 HCC recurrence (recurrence in liver) 4   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.9.1 Laser versus radiofrequency ablation 1 140 Odds Ratio (M‐H, Fixed, 95% CI) 0.86 [0.39, 1.86]
2.9.2 Percutaneous alcohol injection versus radiofrequency ablation 1 232 Odds Ratio (M‐H, Fixed, 95% CI) 1.70 [0.96, 3.00]
2.9.3 Radiofrequency ablation plus chemotherapy versus radiofrequency ablation 1 27 Odds Ratio (M‐H, Fixed, 95% CI) 0.36 [0.07, 1.82]
2.9.4 Transarterial chemoembolisation plus radiofrequency ablation versus radiofrequency ablation 1 40 Odds Ratio (M‐H, Fixed, 95% CI) 1.22 [0.35, 4.24]
2.10 Length of hospital stay 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.10.1 Percutaneous alcohol injection versus radiofrequency ablation 1 232 Mean Difference (IV, Fixed, 95% CI) 15.30 [13.23, 17.37]