Chen 2006.
Study characteristics | ||
Methods | Randomised clinical trial | |
Participants | Country: China Number randomised: 180 Postrandomisation dropouts: 19 (10.6%) Revised sample size: 180 Average age: 51 years Females: 30 (16.7%) Cirrhosis: not stated Very early HCC: not stated Portal hypertension: not stated Viral aetiology: not stated Immunotherapy/antiviral adjuvant therapy: not stated Average follow‐up period in months (for all groups): mean: 29 months Criteria for early or very early HCC and other inclusion criteria:
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Interventions | Participants were randomly assigned to 2 groups: Group 1: surgery (n = 90). Further details: open surgical resection. Group 2: radiofrequency ablation (n = 71). Further details: radiofrequency ablation using RF 2000 or LeVeen (RadioTherapeutics). | |
Outcomes | The outcomes reported were:
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Quote: "Randomization was done by using random numbers generated from a computer in a central registry for this study" |
Allocation concealment (selection bias) | Unclear risk | Comment: this information was not available. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Comment: this information was not available. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comment: this information was not available. |
Incomplete outcome data (attrition bias) All outcomes | High risk | Comment: there were postrandomisation dropouts. |
Selective reporting (reporting bias) | Low risk | Comment: important clinical outcomes were reported. |
For‐profit bias | Low risk | Quote: "Supported by the grant of Sciences and Technology Committee of Guangdo Province, China, 2002." |
Other bias | Low risk | Comment: no other bias noted. |