Leon 1990.

Methods	Duration of the intervention: 1 July 1987 to 1 August 1989 Patients excluded/patients randomized: 0/51 (0%) Sample size calculation/method description: No/No
Participants	Patients randomized: 51 Age (mean): 62 years Sex: not reported Inclusion criteria: patients with severe infections treated with broad spectrum antibiotic therapy Exclusion criteria: not stated Percentage post‐surgical: 18% Percentage colonized with Candida at baseline: 50%
Interventions	1. Amphotericin B orally 2 g daily (n = 24) 2. Placebo (n = 27) Duration of the intervention: not reported
Outcomes	Mortality Proven IFI Superficial fungal infection Follow‐up duration: until ICU discharge
Type of antifungal treatment	Empiric
Funding sources	Not reported
Declaration of interest among the primary researchers	Not reported
Notes	Country: France Setting: single hospital, adult ICU
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Comment: patients randomized according to a randomization table
Allocation concealment (selection bias)	Unclear risk	Comment: insufficient information to permit a judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Comment: insufficient information to permit a judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Comment: insufficient information about blinding of outcome assessment
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: no missing data outcome
Selective reporting (reporting bias)	Low risk	Comment: the study protocol was not available but it is clear that the published report included all expected outcomes
Other bias	Low risk	Comment: the study appeared free of other sources of bias