Havlicek 2008.

Methods	Two‐arm single centre randomized trial
Participants	147 critically ill cancer, burned and trauma patients who had reached a RSS ≥ 10 Exclusion criteria: RSS ≤ 10
Interventions	Group 1: Itraconazole 200 mg orally two times a day Group 2: no antifungal treatment
Outcomes	Fungal colonization Fungal infection Mortality
Notes	One of the criteria for evaluating RSS used by the investigator was the presence of neutropenia. We could not know the percentage of included neutropenic patients. Contact: Havlicek K, Department of Surgery, Institute of Medical Studies, Pardubice General Hospital, Pardubice, Czech Republic PubMed: 19731862