Whitby 2005.
Methods | Two‐arm single centre randomized controlled study |
Participants | Males and females with highly suspected or confirmed invasive fungal infection. Patients' clinical characteristics not stated |
Interventions | Liposomal amphotericin B or conventional amphotericin B for a minimum of 14 days. Salvage therapy (AmBisome 5 mg/kg/day). Total duration of therapy depends on the infection and the patient's condition |
Outcomes | Primary outcome: rate of treatment‐related adverse events Secondary outcome: Microbiological & Clinical Evaluation measured during double blind period and rescue period |
Notes | Target sample size: 104. Recruitment status: completed. Contact: Michael Whitby, Infectious Diseases Department, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, QLD, Australia |
APACHE = acute physiology and chronic health evaluation
Cfu = colony forming units
CI = colonization index
ICU = intensive care unit
IFI = invasive fungal infection
kU = kilounits
RSS = risk severity score