Lass‐Flörl 2013.

Trial name or title	Micafungin‐De‐escalation study: Evalutating the rate of breakthrough infections of micafungin followed by fluconazole versus fluconazole (or other azoles) in febrile patients
Methods	Two‐arm multicentre randomized controlled trial
Participants	Adult patients who are suspicious of suffering from invasive fungal infections
Interventions	1) Micafungin followed by fluconazole 2) Fluconazole (or other azoles)
Outcomes	Rate of breakthrough fungal infections, length of ICU stay, length of in‐hospital stay, fungal colonization index, total days of antifungal treatment, change from baseline values of the SOFA score, incidence of drug‐related unexpected serious adverse events, survival rate
Starting date	May 2013
Contact information	Cornelia Lass‐Flörl, Medizinische Universität Innsbruck, Abteilung für Hygiene und Medizinische Mikrobiologie, Innsbruck, Austria
Notes	Target Sample size: 190 patients