Table 3:

Tests of fixed effects in LMM 3.1

	Groupa		Agea		Interaction
ROIa	F	P	F	p	F	p
WM	4.4	<0.05	405.2	<0.00001	9.6	<0.00001
Thalamus	3.7	<0.05	108.8	<0.00001	8.2	<0.00001
Globus pallidus	1.6	0.2	148.4	<0.00001	3.7	<0.05
Brainstem	1.1	0.3	700.7	<0.00001	3.9	<0.05
Cerebellum	1.6	0.2	120.5	<0.00001	1	0.4
Amygdala	1.6	0.2	12.7	<0.01	3.2	<0.05
Cortex	1.9	0.2	11.4	<0.01	2.2	0.1
Putamen	0.8	0.4	10.8	<0.01	1.9	0.2
Caudate	2.3	0.1	0.7	0.4	0.7	0.5
Hippocampus	1.8	0.2	0.2	0.6	2.3	0.1

The table includes the results of the test for fixed effects used in the LMM3.1: age, group, and age × group interaction. Note that the volume of a single ROI was used as a dependent variable in LMM3.1.

^aThe degrees of freedom for the numerator and denominator are 1 and 123 (age), 2 and 96 (group), and 2 and 123 (interaction), respectively. Note that only p values <0.005 were considered significant (adjustment for 10 ROIs included in the analysis).