Table 5:

Estimates of fixed effects in LMM 3

CTR					NHD				HD
ROI	β	SE	p	95% CI	β´	SE	Adjusted p	95% CI	β´	SE	Adjusted p	95% CI
WM	0.6	0.050	<0.00001	0.5-0.7	−0.07	0.06	0.44	−0.2 to 0.04	−0.25	0.06	<0.00001	−0.4 to −0.13
Thalamus	0.06	0.007	<0.00001	0.04-0.07	−0.02	0.01	<0.01	−0.4 to −0.01	−0.03	0.01	<0.00001	−0.05 to −0.02

The table includes the results obtained with the LMM 3.1 with random intercept and fixed effect of age, group, and their interaction on V of the ROIs. β´ = βNHD or HD-βCTR. The rate of volume change is expressed as milliliters per year. Average estimated age-dependent growth trajectories obtained in the NHD and HD groups were compared with those of the CTR group, with t test and p values adjusted accordingly.