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. 2019 Apr 9;6(2):ENEURO.0025-19.2019. doi: 10.1523/ENEURO.0025-19.2019

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Copyright © 2019 Holland et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Axotomy-induced PTEN deletion and improves functional recovery following sciatic nerve crush. A, B, While there was no difference in recovery of reflex nociception or grasping in mice with floxed PTEN alleles (log rank Mantel–Cox test, n = 14 and n = 9 for ATF3^+/cre:PTEN^+/+ and ATF3^+/cre:PTEN^fl/fl, respectively), EMG responses (C–G) indicated enhanced recovery of neuromuscular function. C, D, Representative EMG traces from ipsilateral and contralateral sides of an ATF3^+/cre:PTEN^+/+ mouse 28 d after sciatic nerve crush (C) and composite traces from eight ATF3^+/cre:PTEN^+/+ mice and six ATF3^cre/cre:PTEN^fl/fl mice. E–G, Ipsilateral/contralateral ratios of EMG thresholds (E), peak EMG latencies (F), and maximum CMAP amplitudes (G) all indicated more complete muscle reinnervation 28 d after injury; n = 8 and n = 6 for ATF3^+/cre:PTEN^+/+ and ATF3^+/cre:PTEN^fl/fl, respectively, averages were compared using paired t tests and ipsilateral/contralateral ratios with unpaired t tests.