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Axotomy-induced PTEN deletion and anatomic regeneration following sciatic nerve crush. A, B, Axonal regeneration 2 d subsequent to sciatic nerve crush (dotted line) was significantly enhanced in ATF3+/cre:PTENfl/fl mice. In C, bar graphs represent the cumulative density of SCG10 immunoreactivity from 0 μm (the distal extent of the crush site) to 2000 μm; n = 6 for both groups and cumulative densities were compared using an unpaired t test. Scale bars: 500 μm.
