2. Indirect comparisons of the diagnostic accuracy of the 10 most evaluated first trimester ultrasound markers alone or in combination with first trimester serum tests.
|
Ratio of DORs (95% CI); P value |
Nasal bone | NT | Nasal bone and age | Ductus and age | NT and age | NT, nasal bone and age | NT, free ßhCG and age | NT, PAPP‐A and age | NT, PAPP‐A, free ßhCG and age | |
|
DOR (95% CI) Studies |
132 (71, 245) K = 11 | 45 (31, 67) K = 13 | 40 (7, 224) K = 4 | 41 (18, 92) K = 5 | 46 (37, 57) K = 50 | 66 (24, 180) K = 5 | 65 (51, 84) K = 5 |
80 (59, 109) K = 5 |
133 (114, 155) K = 69 |
|
| NT | 45 (31, 67) K = 13 | 0.34 (0.16, 0.71); P = 0.006 | ||||||||
| Nasal bone and age | 40 (7, 224) K = 4 | 0.31 (0.05, 1.90); P = 0.18 | 0.90 (0.16, 5.05); P = 0.89 | |||||||
| Ductus and age | 41 (18, 92) K = 5 | 0.31 (0.11, 0.87); P = 0.03 | 0.90 (0.37, 2.20); P = 0.80 | 1.00 (0.11, 9.34); P = 1.00 | ||||||
| NT and age | 46 (37, 57) K = 50 | 0.35 (0.19, 0.66); P = 0.002 | 1.02 (0.66, 1.58); P = 0.92 | 1.14 (0.23, 5.61); P = 0.87 | 1.14 (0.52, 2.49); P = 0.74 | |||||
| NT, nasal bone and age | 66 (24, 180) K = 5 | 0.50 (0.14, 1.81); P = 0.26 | 1.47 (0.47, 4.58); P = 0.48 | 1.64 (0.12, 21.5); P = 0.62 | 1.64 (0.33, 8.08); P = 0.46 | 1.43 (0.52, 3.98); P = 0.48 | ||||
| NT, free ßhCG and age | 65 (51, 84) K = 5 |
0.49 (0.25, 0.98); P = 0.04 | 1.44 (0.89, 2.34); P = 0.12 | 1.61 (0.26, 10.1); P = 0.56 | 1.61 (0.65, 3.99); P = 0.26 | 1.41 (1.02, 1.96); P = 0.04 | 0.98 (0.30, 3.19); P = 0.98 | |||
| NT, PAPP‐A and age | 80 (59, 109) K = 5 | 0.61 (0.29, 1.25); P = 0.16 | 1.77 (1.05, 3.00); P = 0.04 | 1.98 (0.30, 13.1); P = 0.42 | 1.98 (0.76, 5.15); P = 0.14 | 1.73 (1.19, 2.53); P = 0.005 | 1.21 (0.35, 4.13); P = 0.73 | 1.23 (0.74, 2.05); P = 0.35 | ||
| NT, PAPP‐A, free ßhCG and age | 133 (114, 155) K = 69 |
1.00 (0.55, 1.84); P = 1.00 | 2.93 (1.96, 4.40); P < 0.0001 | 3.27 (0.68, 15.8); P = 0.14 | 3.27 (1.53, 7.00); P = 0.003 | 2.87 (2.21, 3.72); P < 0.0001 | 2.00 (0.73, 5.45); P = 0.17 | 2.03 (1.52, 2.72) P < 0.0001 |
1.65 (1.17, 2.34) P = 0.005 |
|
| NT, PAPP‐A, free ßhCG, ADAM 12 and age | 85 (58, 124) K = 4 | 0.64 (0.30, 1.37); P = 0.23 | 1.88 (1.07, 3.32); P = 0.03 | 2.10 (0.31, 14.1); P = 0.39 | 2.10 (0.78, 5.63); P = 0.12 | 1.84 (1.19, 2.84); P = 0.007 | 1.28 (0.37, 4.47); P = 0.65 | 1.30 (0.81, 2.09) P = 0.26 |
1.06 (0.61, 1.86) P = 0.81 |
0.64 (0.43, 0.96) P = 0.03 |
Indirect comparisons were made using all available data for each pair of tests. Ratios of diagnostic odds ratios (DORs) were computed by division of the DOR for the test in the row by the DOR for the test in the column. If the ratio of DORs is greater than one, then the diagnostic accuracy of the test in the row is higher than that of the test in the column; if the ratio is less than one, the diagnostic accuracy of the test in the column is higher than that of the test in the row.