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. 2017 Mar 6;2017(3):CD012031. doi: 10.1002/14651858.CD012031.pub2

Al‐Najashi 1996.

Methods Randomisation and allocation concealment: no information provided
Blinding of outcome assessment: unclear
Documentation of exclusion: no loss to follow‐up
Participants 189 women with an uncomplicated twin pregnancy between 22‐26 weeks' gestation were recruited into the study.
Women with hypertension, diabetes, cardiac disease or antepartum haemorrhage were excluded.
Interventions Women were allocated into 2 intervention groups.
  1. Prophylactic oral ritodrine 10 mg 3 times/d starting from the 25th week until the end of the 37th week of gestation. Women in this group were not restricted in any of their activities.

  2. Hospitalisation from 28‐32 weeks' gestation


Women allocated to the control group received no medication or hospitalisation for bed rest and were seen regularly in the outpatient clinic until delivery. No restriction in any of their activities
All women received abdominal ultrasound for confirmation of diagnosis of booking, and 1 or 2 subsequent ultrasounds to monitor fetal growth.
Outcomes
  1. Gestational age at delivery

  2. Birthweight

  3. Preterm birth

  4. Caesarean section rate

  5. Perinatal mortality

Notes Study design is unclear
Chorionicity: not reported
Sample‐size calculation: not performed
Intention‐to‐treat analyses: performed
 Compliance: 5 women (8%) in the ritodrine group did not take their tablets at the beginning due to side effects. 12 women (21%) in the hospitalisation group did not complete their hospital stay
 Location: single centre in Al‐Khobar, Saudi Arabia
 Timeframe: July 1986‐August 1994