Study	Reason for exclusion
Abumossalam 2016	Non‐randomized prospective clinical study
Cardoso 2007	Case series
Choong 2005	Animal study
Choong 2006	Animal study
Choong 2008	In vitro study
Criner 2009	Open‐labeled, multicenter phase 2 dose. Not RCT
De Oliveira 2006	Longitudinal case series
Deslee 2014	Feasibility study
Emery 2010	Animal study
Faisal 2016	Retrospective study
Falkenstern‐Ge 2013	N=1 study
Fann 2003	Animal study
Fruchter 2016	Retrospective analysis
Gompelmann 2010	Feasibility study
Gompelmann 2012	Retrospective analysis
Gompelmann 2013	Retrospective analysis
Hartman 2015	Long‐term follow‐up of pilot studies
Herth 2010	Single‐arm pilot study
Herth 2011	Phase I: Dose escalation study
Herth 2012	Case series
Hopkinson 2005	Case series
Hopkinson 2011	Case series
Klooster 2014	Feasibility trial
Kontogianni 2014	Retrospective analysis
Kotecha 2011	Retrosepctive cohort
Kramer 2012	Single arm, prospective study
Kramer 2013	Retrospective analysis
Magnussen 2012	Retrospective analysis
Pizarro 2015	Observational study
Refaely 2010	Non‐randomized open label phase 2 trial
Reilly 2007	Non‐randomized open label phase 1 trial
Rendina 2003	Case series
Slebos 2012	Single‐arm pilot study
Snell 2003	Case series
Snell 2009	Feasibility trial
Snell 2012	Open‐label, single‐arm safety and efficacy clinical trials
Springmeyer 2009	Case series
Toma 2003	Single‐arm pilot study
Venuta 2005	Prospective, nonrandomized, single‐center longitudinal study
Venuta 2011	Case series
Wan 2006	Retrospective analysis
Wood 2007	Non randomized multicentre study
Yim 2004	Case series