ISRCTN19684749.

Trial name or title	ISRCTN19684749: Comparative effectiveness of lung volume reduction surgery for emphysema and bronchoscopic lung volume reduction with valve placement
Methods	Randomized parallel trial. Follow‐up: unknown. Estimated enrolment: 152 participants Sites: hospitals in UK
Participants	Participants suffering from heterogeneous emphysema: 1. Adults (aged 18 or over) with COPD 2. FEV1 < 60% predicted 3. Significant hyperinflation (TLC > 100% predicted, RV > 170% predicted) 4. Ex‐smoker > 3 months 5. MRC dyspnoea score of 3 or more 6. CT scan assessed to have intact interlobar fissures (> 90%) and heterogeneous emphysema 7. Provision of informed consent to participate
Interventions	Lung volume reduction surgery versus endobronchial valves: Participants will be randomized to either unilateral video assisted thoracoscopic (VATS) lung volume reduction surgery (LVRS) or endobronchial valves (BLVR) placed to achieve lobar occlusion.
Outcomes	Primary: Change in iBODE score (a composite of BMI, FEV1, MRC dyspnoea score and shuttle walk test distance) one year post‐procedure. Secondary: Health‐related quality of life is measured using the COPD assessment test score (CAT) Physical activity level Change in residual volume (RV) Fat‐free mass
Starting date	April 2016
Contact information	Dr Nick Hopkinson
Notes	ISRCTN19684749