4. Unintended consequences of ITS studies: other.

Study	Prescribing target	Design of analysis	Effect measure	Effect estimate	95% CI
Bell 2014	Antibiotic choice	ITS, segmented regression	Risk of postoperative acute kidney injury	Increase 98%	93.8% to 94.2%
Van Kasteren 2005	Exposure, duration	Cohort	Surgical‐site infection	Decrease 0.8%	‐2.2% to 0.6%
Volpe 2012	Time to first antibiotic dose	Cohort	Left without being seen rate	Decrease 0.4%	No data

CI: confidence interval
 ITS: interrupted time series