| Criterion | Evidence | Decision |
| Risk of bias | Effect estimate greater for 3 studies with low/medium risk of bias (Analysis 1.6). | Not serious |
| Imprecision1 | 3318 patients | Not serious, number of patients is > OIS to detect Δ 1 day (3018 patients). |
| Inconsistency2 | All trials: Chi2 = 119.95, df = 13 (P < 0.00001); I2 = 89% | Not serious, most variation is effect size rather than direction (Figure 4). |
| Indirectness | Not serious for effectiveness | Not serious |
| Publication bias | Large trials, few commercially sponsored | Not serious |
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