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. 2017 Feb 9;2017(2):CD003543. doi: 10.1002/14651858.CD003543.pub4

Buyle 2010.

Methods STUDY DESIGN: ITS
Risk of Bias: LOW
Participants PROVIDERS: all physicians in hospital
PARTICIPANTS: all patients receiving IV fluoroquinolones
CLINICAL PROBLEM: switch from IV fluoroquinolones to oral
SETTING: 1 hospital in Belgium
Interventions FORMAT, Interventions: educational meetings; dissemination of guideline; reminders ‐ circumstantial and physical (pre‐printed note placed in patient notes when the patient fulfilled criteria for IV to oral switch). NB: the circumstantial reminder was only implemented on some wards (abdominal surgery, gastro‐enterology, and plastic surgery) over 2 months, and there are no reliable data to estimate the effect of this component.
Intervention Functions: education, enablement (only for the circumstantial reminder), environmental restructuring (only for the circumstantial reminder)
DELIVERER: AMT
COMPARISON: usual care
DESIRED CHANGE: reduce inappropriate
Outcomes PRESCRIBING: Choice: % IV/(IV + oral) fluoroquinolone usage
Notes FINANCIAL SUPPORT: Funding: none. Competing Interest: none declared
ADDITIONAL DATA: email from authors with further information about the intervention
Risk of bias
Bias Authors' judgement Support for judgement
Intervention independent (ITS) ? Low risk  
Analysed appropriately (ITS) ? Low risk Re‐analysed
Shape of effect pre‐specified (ITS) ? Low risk Point of intervention was point of analysis.
Unlikely to affect data collection (ITS) ? Low risk Data for ITS from pharmacy computer (Figure 1). Other data in Tables 2 and 3 not valid, UBA.
Knowledge of the allocation adequately prevented(ITS)? Low risk Data for ITS from pharmacy computer (Figure 1). Other data in Tables 2 and 3 not valid, UBA.
Incomplete outcome data addressed (ITS) ? Low risk Data for ITS from pharmacy computer (Figure 1). Other data in Tables 2 and 3 not valid, UBA.
Free of selected reporting (ITS) ? Low risk Data for ITS from pharmacy computer (Figure 1). Other data in Tables 2 and 3 not valid, UBA.
Free of other bias (ITS) ? Low risk 21 months' pre‐ and 24 months' postintervention