Chan 2015.

Methods	STUDY DESIGN: ITS Risk of Bias: LOW
Participants	PROVIDERS: all physicians in the hospital PARTICIPANTS: all patients requring vancomycin CLINICAL PROBLEM: patients requiring more than 2 doses of vancomycin treatment SETTING: 1 university hospital in the USA
Interventions	FORMAT Interventions: restrictive ‐ expert approval Intervention Functions: restriction DELIVERER: AMT COMPARISON: pre‐existing antimicrobial stewardship programme with audit and feedback. No valid data about impact of this programme (UBA). DESIRED CHANGE: decrease excessive
Outcomes	PRESCRIBING: Choice: use of vancomycin in DDD/1000 OBD
Notes	FINANCIAL SUPPORT: none. Competing Interests: none declared ADDITIONAL DATA: no response from authors to request for additional data
Risk of bias
Bias	Authors' judgement	Support for judgement
Intervention independent (ITS) ?	Low risk
Analysed appropriately (ITS) ?	Low risk	Segmented regression analysis
Shape of effect pre‐specified (ITS) ?	Low risk
Unlikely to affect data collection (ITS) ?	Low risk	Routine data from pharmacy computer
Knowledge of the allocation adequately prevented(ITS)?	Low risk	Routine data from pharmacy computer
Incomplete outcome data addressed (ITS) ?	Low risk	Routine data from pharmacy computer
Free of selected reporting (ITS) ?	Low risk	Routine data from pharmacy computer
Free of other bias (ITS) ?	Low risk	21 months' pre‐ and 51 months' postintervention data