Parienti 2011.

Methods	STUDY DESIGN: ITS Risk of Bias: LOW
Participants	PROVIDERS: all physicians in the hospital PARTICIPANTS: all patients receiving antibiotics in the hospital CLINICAL PROBLEM: use of fluoroquinolones; the aim of the study was to assess the effect of removing restriction SETTING: 1 university hospital in France
Interventions	FORMAT: no reliable prescribing data. The intervention was removal of restriction, but only 1 prescribing outcome data point during restriction and 3 after restriction lifted. DELIVERER: AMT COMPARISON: usual care DESIRED CHANGE: decrease excessive
Outcomes	MICROBIAL: monthly MRSA rate (%)
Notes	FINANCIAL SUPPORT:Funding: Centre Hospitalier Universitaire de Caen and the French Health Ministry (Programme Hospitalier de Recherche Clinique National). Competing Interests: none declared ADDITIONAL DATA: no response from authors to request for additional data
Risk of bias
Bias	Authors' judgement	Support for judgement
Intervention independent (ITS) ?	Low risk
Analysed appropriately (ITS) ?	Low risk	Segmented regression analysis
Shape of effect pre‐specified (ITS) ?	Low risk	Point of intervention was point of analysis.
Unlikely to affect data collection (ITS) ?	Low risk	MRSA data from microbiology computer
Knowledge of the allocation adequately prevented(ITS)?	Low risk	MRSA data from microbiology computer
Incomplete outcome data addressed (ITS) ?	Low risk	MRSA data from microbiology computer
Free of selected reporting (ITS) ?	Low risk	MRSA data from microbiology computer
Free of other bias (ITS) ?	Low risk	MICROBIAL RISK OF BIAS: case defiinition Low, planned intervention Low, other infection control Low, use of alchohol‐based hand rub (ABHR) unchanged during period of fluoroquinolone restriction (2001‐2) and for 3 years after restriction lifted (2003‐5). Data are also presented for a further 6 years of increased use of ABHR (2006‐11).