Qu 2012.

Methods	STUDY DESIGN: RCT Risk of Bias: HIGH
Participants	PROVIDERS: all physicians in the ICU PARTICIPANTS: 71 patients with with confirmed severe acute pancreatitis CLINICAL PROBLEM: PCT for guiding duration of antibiotic therapy SETTING: 1 hospital in China
Interventions	FORMAT: Interventions: reminders (circumstantial, decision support algorithm with each PCT test); structural, introduction of PCT testing Intervention Functions: enablement, environmental restructuring DELIVERER: department physician (ICU) COMPARISON: usual care DESIRED CHANGE: decrease excessive
Outcomes	PRESCRIBING: Exposure: duration of all antibiotic treatment CLINICAL: Balancing: mortality and length of stay FINANCIAL: cost of hospitalisation, but no information about cost of intervention
Notes	FINANCIAL SUPPORT: Funding: none. Competing Interests: none declared ADDITIONAL DATA: no response from authors to request for additional data
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Says it was randomised, but no further information
Allocation concealment (selection bias)	Unclear risk	No information
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No mention of blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	Outcomes on all 71 participants
Selective reporting (reporting bias)	Low risk
Other bias	Low risk
Baseline Outcomes similar?	Unclear risk	No information
Free of contamination?	Low risk	PCT results only reported for intervention participants.
Baseline characteristics similar?	Low risk	Yes, Table 1