Boghen 1986.

Methods	Analysis: clonazepam vs placebo Treatment duration: 4 weeks Follow‐up: not reported Center: University of Montreal, Canada Design: randomized clinical trial, double‐blind, cross‐over, placebo‐controlled
Participants	N = 6 Drop out: none Diagnosis: clinically diagnosed Exclusions: pregnant women, and people with systemic illness, such as diabetes and liver or renal diseases Gender: 3 women, 3 men Race: not reported Age (years): 31–61 (mean 46) Setting: University clinic
Interventions	Group 1: (n = 3) clonazepam (4 weeks) followed by placebo (4 weeks) Group 2: (n = 3) placebo (4 weeks) followed by clonazepam (4 weeks) Clonazepam was started at 0.5mg in the 1st week and progressively increased until the 4th week as follows: 1st week 1/2 h before bedtime; 2nd week 18:00 h, 3rd week at 12:00 h, and in the 4th at 8:00 h Placebo = identical appearing Washout = not reported
Outcomes	Self‐rating system in which participants assigned a score daily to the degree of discomfort experienced in the previous 24 h (0‐4)
Notes	Study authors seemed to be aware of the carry‐over effect but they did not state if they allowed for it in the study. We had no success in contacting the study authors for information about the cross‐over results.