Comparison 1. NSAID versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Substantial pain relief	2	146	Risk Difference (M‐H, Fixed, 95% CI)	‐0.07 [‐0.18, 0.04]
2 Moderate pain relief	3	192	Risk Difference (M‐H, Fixed, 95% CI)	‐0.04 [‐0.16, 0.08]
3 Adverse event withdrawal	4	230	Risk Difference (M‐H, Fixed, 95% CI)	0.04 [‐0.02, 0.09]
4 Participants with at least one adverse event	4	230	Risk Difference (M‐H, Fixed, 95% CI)	0.08 [‐0.03, 0.19]
5 All‐cause withdrawal	3	192	Risk Difference (M‐H, Fixed, 95% CI)	0.03 [‐0.07, 0.14]