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. 2017 Mar 23;2017(3):CD006324. doi: 10.1002/14651858.CD006324.pub3

Comparison 2. CLOZAPINE + AMISULPRIDE versus CLOZAPINE + QUETIAPINE.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Clinical response: 1 mean score/change in global state: mean CGI score (high = poor) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.1 Short term (8 weeks) 1 50 Mean Difference (IV, Random, 95% CI) ‐0.90 [‐1.38, ‐0.42]
2 Clinical response: 2a mean score/change in mental state: mean BPRS score (high = poor) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
2.1 Short term (8 weeks) 1 50 Mean Difference (IV, Random, 95% CI) ‐4.0 [‐5.86, ‐2.14]
3 Clinical response: 2b mean score/change in mental state: mean SAPS score (high = poor) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
3.1 Short term (8 weeks) 1 50 Mean Difference (IV, Random, 95% CI) ‐6.90 [‐12.82, ‐0.98]
4 Clinical response: 2c mean score/change in mental state: means SANS score (high = poor) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
4.1 Short term (8 weeks) 1 50 Mean Difference (IV, Random, 95% CI) ‐5.20 [‐7.14, ‐3.26]
5 Leaving the study early: acceptability of treatment ‐ as measured by completion of trial 1 56 Risk Ratio (M‐H, Fixed, 95% CI) 0.2 [0.02, 1.60]