Comparison 2. Dose comparison: oestrogen 100 µg patch vs 200 µg patch plus progestogen in both groups.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Symptoms score: maximum mean daily PDQ	1	98	Mean Difference (IV, Fixed, 95% CI)	‐1.55 [‐8.88, 5.78]
2 Adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Withdrawal rates	1	107	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.34, 1.46]
2.2 Side effects attributed to oestrogen	1	107	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.26, 0.99]
3 Specific symptoms of PMS	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 Psychological symptoms	1	98	Mean Difference (IV, Fixed, 95% CI)	‐0.28 [‐1.17, 0.61]
3.2 Physical symptoms	1	98	Mean Difference (IV, Fixed, 95% CI)	‐0.33 [‐1.17, 0.51]
4 VAS Sense of wellbeing	1	98	Mean Difference (IV, Fixed, 95% CI)	1.70 [‐19.43, 22.83]
5 Patient satisfaction	1	107	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.85, 1.68]