Study	Reason for exclusion
de Lignières 1986	Study addresses effect on migraine, not on global symptoms
Dennerstein 1988	Study addresses effect on migraine, not on global symptoms
Domoney 2003	Study does not include placebo or oestrogen comparator
Ensom 2003	Study addresses effect on asthma not on global symptoms
Halbreich 2012	Study uses oestrogen as part of oral contraceptive