Makrides 1995.

Methods	Single‐centre RCT conducted in Adelaide Sample size calculation: yes Concealment of allocation: yes Blinding to intervention: yes Blinding to outcome assessment: yes Completeness of follow‐up: no (60% to 81% for various primary outcomes)
Participants	N = 32. Inclusion criteria: healthy term appropriate for gestational age infants born at 37 to 42 weeks. Exclusion criteria: infants of mothers who had history of lipid metabolism disorders, diabetes, drug or alcohol abuse LCPUFA supplemented formula: N = 13 (GA 39.1 ± 1.7 weeks, BW 3.288 ± 0.525 kg) Control formula: N = 19 (GA 39.6 ± 1.2 weeks, BW 3.650 ± 0.0416 kg)
Interventions	'LCPUFA' group was given milk formula enriched with DHA (0.35%). In addition, formula was enriched with EPA and GLA. Control group was fed standard milk formula without DHA and AA added. Assigned diets were fed from birth to 30 weeks of life. Source of LCPUFA was fish oil and evening primrose oil
Outcomes	Plasma and red blood cell fatty acid levels at 6, 16 and 30 weeks; visual evoked potential acuity at 16 and 30 weeks; Bayley Scales of Infant Development at 1 year
Notes	Breast‐fed reference group, n = 28
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Use of central computerised randomisation
Allocation concealment (selection bias)	Low risk	Adequate; use of sealed opaque envelopes
Blinding (performance bias and detection bias) All outcomes	Low risk	Mothers were unaware of formula type
Incomplete outcome data (attrition bias) All outcomes	High risk	60% to 81% follow‐up for various primary outcomes
Selective reporting (reporting bias)	Low risk	All prespecified outcomes were reported
Other bias	Low risk	Appears to be free of other biases