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. 2019 Feb 15;18(5):523–530. doi: 10.1080/15384101.2019.1577652

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Hox Interactions mediate collinearity and TST. Above: the sequence of genes in the whole Xenopus A-P axis: Starting anteriorly with the EAD gene XAG1, going on to head genes and finishing, posteriorly, with Hox pralogue groups 1–13. Next down: Hox1 LOF: The whole posterior axis, including Hox1 is deleted or compromised. Gbx2 is upregulated (not shown) Next down: Hoxc6 LOF: The posterior axis from and including Hox6 is deleted. Hoxc4 and Hoxc5 are upregulated (not shown) Next: Hoxb9 GOF in a noggin embryo. A partial axis is generated, starting at Hox9 [5,26,28].