Table 3.
Up-regulated miR-202-3p and knockdown TRPM-6 result in declines in inflammatory response and Troponin.
| Groups | IL-1β/pg•mL−1 | IL-6/pg•mL−1 | TNF-α/pg•mL−1 | Troponin T/pg•mL−1 |
|---|---|---|---|---|
| Sham | 59.05 ± 7.38 | 16.28 ± 2.83 | 10.73 ± 2.73 | 8.96 ± 2.79 |
| I/R injury | 129.36 ± 15.94* | 56.55 ± 6.21* | 51.51 ± 6.78* | 49.39 ± 3.39* |
| NC | 128.79 ± 14.88* | 57.56 ± 6.47* | 50.91 ± 6.95* | 48.47 ± 3.34* |
| miR-202-3p mimic | 89.83 ± 9.94*# | 35.34 ± 4.41*# | 29.57 ± 4.12*# | 26.76 ± 3.21*# |
| siRNA-TRPM6 | 88.43 ± 9.14*# | 35.14 ± 3.98*# | 30.24 ± 3.12*# | 27.33 ± 3.08*# |
| miR-202-3p inhibitor | 184.45 ± 23.05*# | 83.34 ± 13.14*# | 78.78 ± 8.91*# | 76.22 ± 4.12*# |
| miR-202-3p inhibitor + siRNA- TRPM6 | 129.13 ± 16.14* | 56.34 ± 8.66* | 51.76 ± 6.32* | 50.29 ± 3.29* |
*, p < 0.05 vs. the sham group; #, p < 0.05 vs. the I/R injury group; n = 5; multiple groups were compared by one-way analysis of variance followed by a Tukey’s post hoc test; NC, negative control; miR-202-3p, microRNA-202-3p; TRPM6, transient receptor potential cation channel, subfamily M, member 6; IL-1β, interleukin 1 beta; IL-6, interleukin 6; TNF-α, tumor necrosis factor-α.