1. Penile Neoplasms/su [Surgery]

2. exp Penis tumor/su [surgery]

3. or/1‐2

4. exp penis tumor/

5. ((penis or penile) adj4 (cancer$ or carcinoma$ or tumo?r$ or neoplas$)).tw.

6. ((penile or penis) adj2 (squamous cell carcinoma or scc)).tw.

7. or/4‐6

8. exp Fluorouracil/

9. (5‐fu or Efudix or Aldara or Zydara).tw.

10. imiquimod/

11. (laser adj3 (excision or vapo?ri?ation)).tw.

12. chemosurgery/

13. ((Mohs adj4 surgery) or mms or Moh's paste).tw.

14. (moh$ and (surgery or technique)).tw.

15. imiquimod.tw.

16. (intraoperative chemotherapy or chemical surgery or chemosurgery).tw.

17. (glans adj3 resurfac$).tw.

18. glansectomy.tw.

19. penis amputation/

20. penectomy.tw.

21. excision/

22. (excision adj3 primary closure).tw.

23. or/8‐22

24. exp clinical trial/

25. randomization/

26. randomi?ed.ab.

27. placebo.ab.

28. drug therapy.fs.

29. randomly.ab.

30. trial.ab.

31. groups.ab.

32. Treatment outcome/

33. major clinical study/

34. controlled study/

35. clinical trial/

36. (preoperat$ or pre operat$).tw.

37. (chang$ or evaluat$ or reviewed or baseline).tw.

38. (prospective$ or retrospective$).tw.

39. (cohort$ or case series).tw.

40. (compare$ or compara$).tw.

41. case report/

42. or/24‐41

43. 7 and 23 and 42

44. 3 and 42

45. 43 or 44

46. exp animals/ not humans/

47. 45 not 46