Table 1.
Adverse effects on valproate: number of participants experiencing each event
| Event | Callaghan 1982 | Sato 1982 | Martinovic 1983 | Coppola 2004 | Huang 2009 | Glauser 2013 |
| Acute pancreatitis | 1 | |||||
| Obesity/Weight gain | 1 | 1 | 14 | |||
| Drowsiness | 4 | |||||
| Nausea | 5 | 3 | 12* | |||
| Vomiting | 1 | 2 | 12* | |||
| Decreased platelet numbers | 2 | 4 | ||||
| Increased appetite | 15 | |||||
| Poor appetite | 1 | 8 | ||||
| Diarrhoea | 1 | 7 | ||||
| Dizziness | 1 | 2 | ||||
| Hyperactivity | 23 | |||||
| Attention problems | 24 | |||||
| Hostility | 22 | |||||
| Concentration decreased | 18 | |||||
| Personality change | 17 | |||||
| Sleep problem | 17 | |||||
| Depression | 11 | |||||
| Slow process speed | 11 | |||||
| Memory problem | 10 | |||||
| Apathy | 9 | |||||
| Fatigue | 27 | |||||
| Headache | 1 | 18 | ||||
| Leukopenia | 2 | |||||
| Elevated liver function tests | 1 | 7 | ||||
| Elevated LDH | 1 | |||||
| Rash | 2 |
* Nausea, vomiting, or both LDH: lactate dehydrogenase
Numbers of individuals within each study undertaking valproate: 14 (Callaghan 1982), 22 (Sato 1982), 10 (Martinovic 1983), 19 (Coppola 2004), 23 (Huang 2009), 146 (Glauser 2013a).