. 2019 Mar 22;8:e45399. doi: 10.7554/eLife.45399

Table 1. Acute, adult hypoxic phrenic responses.

Table 1—source data 1. Hypoxic responses.

elife-45399-table1-data1.xlsx^{(10.1KB, xlsx)}

DOI: 10.7554/eLife.45399.020

	Male		Female †††
	Neonatal saline	Neonatal LPS	Neonatal saline	Neonatal LPS
Moderate hypoxia	114 ± 41	93 ± 36	185 ± 53^*	148 ± 63
Keto + Moderate hypoxia	118 ± 36	118 ± 44	165 ± 52	189 ± 82^*
	Male		Female †
	Neonatal Saline	Neonatal LPS	Neonatal Saline	Neonatal LPS
Severe hypoxia	139 ± 37	106 ± 10	172 ± 125	172 ± 26
Keto + Severe hypoxia	151 ± 25	174 ± 96	194 ± 45	235 ± 63

Group data for adult, acute hypoxic phrenic responses to moderate (PaO₂35–45 mmHg) and severe (PaO₂25–35 mmHg) hypoxia demonstrate no differences after neonatal (P4) saline or LPS (1 mg/kg, i.p), or after adult ketoprofen (12.5 mg/kg, i.p, 3 hr) within each sex. Significant differences between sexes demonstrate larger responses in females after moderate or severe hypoxia († p<0.05, ††† p<0.001). *p<0.05 from male neonatal LPS. Moderate hypoxia: neonatal saline male (n = 7), neonatal LPS male (n = 10), neonatal saline female (n = 6), neonatal LPS female (n = 6). Keto + Moderate hypoxia: neonatal saline male (n = 4), neonatal LPS male (n = 4), neonatal saline female (n = 5), neonatal LPS female (n = 5). Severe hypoxia: neonatal saline male (n = 5), neonatal LPS male (n = 4), neonatal saline female (n = 4), neonatal LPS female (n = 4). Keto + Moderate hypoxia: neonatal saline male (n = 5), neonatal LPS male (n = 5), neonatal saline female (n = 5), neonatal LPS female (n = 6).