. 2019 Mar 22;8:e45399. doi: 10.7554/eLife.45399

Table 2. Physiological parameters during electrophysiology experiments.

Table 2—source data 1. Physiological parameters.

elife-45399-table2-data1.xlsx^{(33.1KB, xlsx)}

DOI: 10.7554/eLife.45399.022

		Temperature (°C)		P_aO₂ (mmHg)		P_aCO₂ (mmHg)		pH		MAP (mmHg)
Baseline		Male	Female	Male	Female	Male	Female	Male	Female	Male	Female
	Neonatal Saline + mAIH	37.4 ± 0.2	37.4 ± 0.2	254 ± 19	259 ± 53	43.2 ± 5.6	48.9 ± 3.7	7.37 ± 0.06	7.36 ± 0.02	124 ± 9	121 ± 18
	Neonatal LPS + mAIH	37.6 ± 0.2	37.5 ± 0.2	266 ± 30	268 ± 24	42.8 ± 4.7^#	45.0 ± 1.8	7.37 ± 0.04	7.37 ± 0.02	127 ± 10	123 ± 23
	Neonatal Saline + Keto + mAIH	37.3 ± 0.1	37.4 ± 0.3	249 ± 21	255 ± 28	41.7 ± 4.9	48.6 ± 3.5	7.38 ± 0.03	7.33 ± 0.02	132 ± 8	121 ± 12
	NeonatalLPS + Keto + mAIH	37.4 ± 0.2	37.4 ± 0.3	276 ± 40	283 ± 33	41.5 ± 3.2	47.9 ± 3.6	7.39 ± 0.03	7.34 ± 0.02	129 ± 16	117 ± 14
	Neonatal Saline + sAIH	37.6 ± 0.3	37.5 ± 0.2	295 ± 18	266 ± 9	43.3 ± 5.9	47.7 ± 3.1	7.37 ± 0.02	7.36 ± 0.00	133 ± 6	121 ± 19
	Neonatal LPS + sAIH	37.4 ± 0.1	37.4 ± 0.4	297 ± 28	264 ± 35	45.3 ± 4.2	47.7 ± 4.0	7.36 ± 0.02	7.36 ± 0.02	135 ± 20	132 ± 14
	Neonatal Saline + Keto + sAIH	37.4 ± 0.3	37.5 ± 0.1	256 ± 46	268 ± 29	41.6 ± 2.2^e	49.9 ± 3.5	7.39 ± 0.03	7.34 ± 0.02	110 ± 12	113 ± 29
	NeonatalLPS + Keto + sAIH	37.5 ± 0.2	37.4 ± 0.2	243 ± 45	245 ± 39	42.3 ± 3.4	51.6 ± 6.8	7.37 ± 0.01	7.31 ± 0.04	121 ± 3	129 ± 13
	NeonatalSaline + CGS-21680	37.5 ± 0.2	37.3 ± 0.2	268 ± 21	237 ± 14	45.4 ± 5.3	46.2 ± 3	7.36 ± 0.04	7.34 ± 0.03	119 ± 24	121 ± 10
	Neonatal LPS + CGS-21680	37.6 ± 0.3	37.4 ± 0.3	247 ± 27	247 ± 21	46.2 ± 2.9	46.6 ± 2.7	7.37 ± 0.02	7.34 ± 0.02	114 ± 12	107 ± 15
	Time Controls	37.7 ± 0.1		250 ± 45		49.4 ± 4.0		7.36 ± 0.05		110 ± 10
	Time Controls + Keto	37.5 ± 0.3		250 ± 17		44.0 ± 9.1		7.37 ± 0.06		115 ± 39
	CGS-21680 Vehicle Controls	37.4 ± 0.3		237 ± 40		45.8 ± 0.8		7.37 ± 0.03		110 ± 17
Hypoxia
	Neonatal Saline + mAIH	37.4 ± 0.2	37.3 ± 0.1	38 ± 2^{*,†, ‡}	40 ± 3^{*,†, ‡}	42.2 ± 5.1^#	48.8 ± 3.8	7.35 ± 0.07	7.36 ± 0.03^#	62 ± 23^{*,†, ‡}	65 ± 30^{*,†, ‡}
	Neonatal LPS + mAIH	37.5 ± 0.4	37.4 ± 0.1	39 ± 2^{*,†, ‡}	39 ± 4^{*,†, ‡}	43.0 ± 4.8^#	45.4 ± 2.8	7.36 ± 0.04^#	7.36 ± 0.02^#	68 ± 19^{*,†, ‡}	80 ± 21^‡
	Neonatal Saline + Keto + mAIH	37.5 ± 0.2	37.4 ± 0.3	38 ± 1^{*,†, ‡}	39 ± 3^{*,†, ‡}	41.9 ± 3.5	48.6 ± 3.7	7.37 ± 0.03^#	7.32 ± 0.04	62 ± 11^‡	56 ± 6^{*,†, ‡}
	NeonatalLPS + Keto + mAIH	37.5 ± 0.2	37.5 ± 0.3	40 ± 2^{*,†, ‡}	39 ± 4^{*,†, ‡}	40.9 ± 2.2^#	47.8 ± 4.9	7.36 ± 0.04	7.32 ± 0.03	71 ± 14^‡	66 ± 19^‡
	Neonatal Saline + sAIH	37.6 ± 0.2	37.4 ± 0.3	29 ± 5^{*,†, ‡}	29 ± 2^{*,†, ‡}	43.5 ± 5.9	47.7 ± 2.3	7.35 ± 0.03	7.32 ± 0.06	58 ± 9^{*,†, ‡}	53 ± 11^{*,†, ‡}
	Neonatal LPS + sAIH	37.4 ± 0.3	37.5 ± 0.3	30 ± 4^{*,†, ‡}	31 ± 5^{*,†, ‡}	46.3 ± 4.2	47.3 ± 5.9	7.34 ± 0.03	7.31 ± 0.03	61 ± 20^‡	59 ± 20^{*,†, ‡}
	Neonatal Saline + Keto + sAIH	37.4 ± 0.2	37.5 ± 0.2	30 ± 2^{*,†, ‡}	32 ± 3^{*,†, ‡}	42.3 ± 2.2^#	48.9 ± 3.7	7.36 ± 0.03	7.29 ± 0.03	34 ± 8^{*,†, ‡,¶}	45 ± 29^{*,†, ‡}
	NeonatalLPS + Keto + sAIH	37.3 ± 0.3	37.6 ± 0.2	31 ± 2^{*,†, ‡}	32 ± 1^{*,†, ‡}	42.2 ± 3.2^#	52.2 ± 5.8	7.34 ± 0.03	7.28 ± 0.06	37 ± 11^{*,†, ‡,¶}	43 ± 21^{*,†, ‡}
	Time Controls	37.6 ± 0.3		226 ± 40		48.7 ± 4.7		7.35 ± 0.04		107 ± 13
	Time Controls + Keto	37.5 ± 0.2		258 ± 13		45.5 ± 9.3		7.37 ± 0.06^#		109 ± 44
60 min
	Neonatal Saline + mAIH	37.5 ± 0.4	37.3 ± 0.1	234 ± 28	259 ± 22	43.4 ± 5.7	48.6 ± 3.7	7.38 ± 0.05^#	7.35 ± 0.02	114 ± 9	117 ± 27
	Neonatal LPS + mAIH	37.5 ± 0.3	37.4 ± 0.3	253 ± 19	268 ± 23^*	42.9 ± 4.4^#	45.2 ± 2.6	7.39 ± 0.04^#	7.37 ± 0.01	116 ± 14	121 ± 25
	Neonatal Saline + Keto + mAIH	37.3 ± 0.2	37.3 ± 0.3	262 ± 14	257 ± 32	42.5 ± 4.9	48.7 ± 4.0	7.38 ± 0.01	7.33 ± 0.04	121 ± 13	115 ± 11
	NeonatalLPS + Keto + mAIH	37.6 ± 0.3	37.6 ± 0.3	257 ± 18	276 ± 40^*	41.5 ± 2.7	47.8 ± 3.6	7.36 ± 0.02	7.34 ± 0.06	123 ± 11	112 ± 18
	Neonatal Saline + sAIH	37.5 ± 0.3	37.4 ± 0.2	262 ± 36	258 ± 19	43.7 ± 5.5	47.6 ± 2.9	7.37 ± 0.04	7.32 ± 0.03	135 ± 9	115 ± 24
	Neonatal LPS + sAIH	37.7 ± 0.2	37.4 ± 0.2	282 ± 16^*	266 ± 18	46.2 ± 4.8	47.7 ± 4.5	7.36 ± 0.02	7.35 ± 0.02	127 ± 14	128 ± 17
	Neonatal Saline + Keto + sAIH	37.7 ± 0.3	37.4 ± 0.3	248 ± 42	262 ± 9	42.3 ± 2.6	50.2 ± 4.2	7.37 ± 0.03	7.32 ± 0.03^§	105 ± 10	109 ± 36
	NeonatalLPS + Keto + sAIH	37.5 ± 0.2	37.4 ± 0.3	252 ± 24	245 ± 21	42.2 ± 3	51.2 ± 6.9	7.38 ± 0.02	7.31 ± 0.04	117 ± 14	125 ± 19
	NeonatalSaline + CGS-21680	37.3 ± 0.3	37.6 ± 0.1	270 ± 46	215 ± 48	45.7 ± 4.9	47 ± 3.3	7.34 ± 0.06	7.35 ± 0.04	112 ± 30	126 ± 21
	Neonatal LPS + CGS-21680	37.4 ± 0.4	37.4 ± 0.4	254 ± 26	256 ± 21	46.1 ± 3.2	46.5 ± 3.2	7.37 ± 0.01	7.33 ± 0.04	107 ± 16	101 ± 25
	Time Controls	37.5 ± 0.3		220 ± 25		48.4 ± 3.7		7.36 ± 0.04		102 ± 22
	Time Controls + Keto	37.6 ± 0.2		272 ± 21		44.3 ± 8.7		7.37 ± 0.07		111 ± 48
	CGS-21680 Vehicle Controls	37.6 ± 0.2		271 ± 27		45.4 ± 1.6		7.36 ± 0.03		108 ± 7

MAP, mean arterial pressure; P_aO_2, arterial oxygen pressure; P_aCO₂, arterial carbon dioxide pressure. Neonatal Saline +mAIH male (n = 7) female (n = 7); Neonatal LPS +mAIH male (n = 12) female (n = 6); Neonatal Saline +Keto + mAIH male (n = 4) female (n = 5); Neonatal LPS +Keto + mAIH male (n = 4) female (n = 5); Neonatal Saline +sAIH male (n = 5) female (n = 4); Neonatal LPS +sAIH male (n = 4) female (n = 4); Neonatal Saline +Keto + sAIH male (n = 5) female (n = 5); Neonatal LPS +Keto + sAIH male (n = 5) female (n = 6); Time Control (n = 5); Time Control + Keto (n = 4). Statistical comparisons: ANOVA-RM, Tukey’s post hoc: ^* different from Time control within time point, ^† different from TC +Keto within time point, ^‡ different from baseline and 60 min, ^§ different from baseline, ^# different from female neonatal LPS +Keto + sAIH within time point, ^¶ different from female LPS within time point.