Comparison 2. LMWH versus UFH in patients with proximal deep venous thrombosis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of recurrent venous thromboembolism at the end of follow‐up	10	4672	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.57 [0.44, 0.75]
1.1 Nadroparin versus unfractionated heparin	3	864	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.72 [0.44, 1.19]
1.2 Tinzaparin versus unfractionated heparin	1	432	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.42 [0.17, 1.01]
1.3 Enoxaparin versus unfractionated heparin	2	634	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.65 [0.32, 1.32]
1.4 Reviparin versus unfractionated heparin	1	763	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.31 [0.15, 0.63]
1.5 Certoparin versus unfractionated heparin	2	1758	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.64 [0.40, 1.03]
1.6 Bemiparin versus unfractionated heparin	1	221	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Incidence of recurrent deep venous thrombosis at the end of follow‐up	7	2681	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.61 [0.41, 0.91]
2.1 Nadroparin versus unfractionated heparin	3	765	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.76 [0.41, 1.43]
2.2 Tinzaparin versus unfractionated heparin	1	432	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.37 [0.12, 1.16]
2.3 Enoxaparin versus unfractionated heparin	1	500	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.74 [0.34, 1.63]
2.4 Reviparin versus unfractionated heparin	1	763	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.45 [0.17, 1.21]
2.5 Bemiparin versus unfractionated heparin	1	221	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.01, 2.14]
3 Incidence of pulmonary embolism at the end of follow‐up	7	3024	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.45 [0.28, 0.74]
3.1 Nadroparin versus unfractionated heparin	2	570	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.65 [0.27, 1.60]
3.2 Tinzaparin versus unfractionated heparin	1	432	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.52 [0.14, 1.95]
3.3 Enoxaparin versus unfractionated heparin	1	500	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.52 [0.05, 5.07]
3.4 Reviparin versus unfractionated heparin	1	763	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.27 [0.10, 0.73]
3.5 Certoparin versus unfractionated heparin	1	538	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.32 [0.11, 0.92]
3.6 Bemiparin versus unfractionated heparin	1	221	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.94 [0.20, 18.86]
4 Reduction in thrombus size (pre‐ and post‐treatment venograms)	2	230	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.47 [0.27, 0.80]
4.1 Bemiparin versus unfractionated heparin	1	203	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.42 [0.24, 0.74]
4.2 Dalteparin versus unfractionated heparin	1	27	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.47 [0.22, 9.90]
5 Incidence of major haemorrhagic episodes (during initial treatment)	8	3589	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.50 [0.29, 0.85]
5.1 Nadroparin versus unfractionated heparin	3	765	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.42 [0.09, 1.85]
5.2 Tinzaparin versus unfractionated heparin	1	432	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.19 [0.06, 0.59]
5.3 Enoxaparin versus unfractionated heparin	2	634	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.70 [0.42, 6.87]
5.4 Certoparin versus unfractionated heparin	2	1758	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.55 [0.26, 1.17]
6 Overall mortality at the end of follow‐up	9	4331	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.63 [0.47, 0.85]
6.1 Nadroparin versus unfractionated heparin	2	570	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.69 [0.38, 1.24]
6.2 Tinzaparin versus unfractionated heparin	1	432	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.48 [0.23, 1.00]
6.3 Enoxaparin versus unfractionated heparin	2	634	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.74 [0.37, 1.50]
6.4 Reviparin versus unfractionated heparin	1	763	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.79 [0.32, 1.91]
6.5 Certoparin versus unfractionated heparin	2	1758	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.54 [0.30, 0.96]
6.6 Bemiparin versus unfractionated heparin	1	174	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.95 [0.13, 6.90]