Comparison 3. LMWH versus UFH in patients with pulmonary embolism.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of recurrent venous thromboembolism at the end of follow‐up	7	1407	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.90 [0.50, 1.61]
1.1 Tinzaparin versus unfractionated heparin	2	680	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.84 [0.26, 2.77]
1.2 Enoxaparin versus unfractionated heparin	3	396	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.89 [0.37, 2.16]
1.3 Dalteparin versus unfractionated heparin	1	60	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.4 Reviparin versus unfractionated heparin	1	271	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.96 [0.35, 2.64]
2 Reduction in thrombus size (pre‐ and post‐treatment venograms)	2	106	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.36 [0.23, 8.16]
2.1 Nadroparin versus unfractionated heparin	1	52	Peto Odds Ratio (Peto, Fixed, 95% CI)	5.53 [0.32, 95.93]
2.2 Dalteparin versus unfractionated heparin	1	54	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.54 [0.05, 5.43]
3 Mean change in pulmonary vascular obstruction severity score	2	106	Mean Difference (IV, Fixed, 95% CI)	‐3.14 [‐4.39, ‐1.90]
3.1 Nadroparin versus unfractionated heparin	1	52	Mean Difference (IV, Fixed, 95% CI)	‐3.28 [‐4.55, ‐2.01]
3.2 Dalteparin versus unfractionated heparin	1	54	Mean Difference (IV, Fixed, 95% CI)	1.0 [‐5.94, 7.94]
4 Incidence of major haemorrhagic episodes (during initial treatment)	3	178	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.44 [0.04, 4.29]
4.1 Nadroparin versus unfractionated heparin	1	68	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.12 [0.01, 2.02]
4.2 Enoxaparin versus unfractionated heparin	1	50	Peto Odds Ratio (Peto, Fixed, 95% CI)	5.61 [0.11, 297.44]
4.3 Dalteparin versus unfractionated heparin	1	60	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Overall mortality at end of follow‐up	3	178	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.70 [0.17, 16.71]
5.1 Nadroparin versus unfractionated heparin	1	68	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.94 [0.06, 15.40]
5.2 Enoxaparin versus unfractionated heparin	1	50	Peto Odds Ratio (Peto, Fixed, 95% CI)	5.61 [0.11, 297.44]
5.3 Dalteparin versus unfractionated heparin	1	60	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]