Comparison 9. LMWH versus UFH: all randomised controlled trials that used ISTH definition of major bleeding.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of major haemorrhagic episodes (during initial treatment)	24	8712	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.71 [0.52, 0.98]
1.1 Nadroparin versus unfractionated heparin	7	1964	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.44 [0.19, 1.01]
1.2 Tinzaparin versus unfractionated heparin	3	1581	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.71 [0.41, 1.22]
1.3 Enoxaparin versus unfractionated heparin	5	1143	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.22 [0.54, 2.75]
1.4 Dalteparin versus unfractionated heparin	4	765	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.15 [0.02, 1.44]
1.5 Reviparin versus unfractionated heparin	1	1021	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.26 [0.49, 3.19]
1.6 Certoparin versus unfractionated heparin	3	2017	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.50 [0.25, 1.00]
1.7 Bemiparin versus unfractionated heparin	1	221	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.39 [0.46, 118.89]