Comparison 10. LMWH versus UFH by year of publication.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of recurrent venous thromboembolism during initial treatment	18	6238	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.69 [0.49, 0.98]
2 Incidence of recurrent venous thromboembolism at the end of follow‐up	22	9489	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.72 [0.59, 0.88]
3 Incidence of major haemorrhagic episodes (during initial treatment)	25	8790	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.69 [0.51, 0.95]
4 Overall mortality at the end of follow‐up	24	9663	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.84 [0.70, 1.01]