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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Sci Signal. 2019 Jan 1;12(562):eaan7984. doi: 10.1126/scisignal.aan7984

Figure 4. CK2α inhibition induces wild-type CFTR degradation.

Figure 4.

Degradation network identified for wild-type CFTR, wild-type CFTR treated with CX-4945, or ΔF508 CFTR in 16HBE41o- and CFBE41o- cells shows recruitment of ΔF508- specific interactions in wild-type CFTR expressing cells treated with CX-4945 (red nodes). Data represent independent biological replicates (wt n=8, ΔF508 n=8, wt+CX-4945 n=3).