Summary of findings 8. Gentamicin sponge compared with primary closure alone for hidradenitis suppurativa.
| Gentamicin sponge compared with primary closure alone for hidradenitis suppurativa | ||||||
| Patient or population: participants with hidradenitis suppurativa Settings: hospital‐based Intervention: gentamicin sponge Comparison: primary closure alone | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Primary closure alone | Gentamicin sponge | |||||
| Adverse effects ‐ complication rate at 1 week after surgery Follow‐up: 1 weeks | Study population | RR 0.78 (0.58 to 1.05) | 200 (1 study) | ⊕⊕⊕⊝ moderate¹ | ‐ | |
| 526 per 1000 | 411 per 1000 (305 to 553) | |||||
| Moderate | ||||||
| 526 per 1000 | 410 per 1000 (305 to 552) | |||||
| Adverse effects ‐ complication rate at 3 months after surgery Follow‐up: 3 months | Study population | RR 0.9 (0.5 to 1.62) | 200 (1 study) | ⊕⊕⊕⊝ moderate¹ | ‐ | |
| 197 per 1000 | 178 per 1000 (99 to 320) | |||||
| Moderate | ||||||
| 197 per 1000 | 177 per 1000 (99 to 319) | |||||
| Recurrence rate at 3 months after surgery Follow‐up: 3 months | Study population | RR 0.96 (0.68 to 1.34) | 200 (1 study) | ⊕⊕⊕⊝ moderate¹ | ‐ | |
| 421 per 1000 | 404 per 1000 (286 to 564) | |||||
| Moderate | ||||||
| 421 per 1000 | 404 per 1000 (286 to 564) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio. | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
¹Downgraded one level due to unclear risk of bias for most domains. In particular, the study report states that there was an imbalance in randomisation due to early cessation of the study, but no further details are provided. Also, no description is provided of any special measures to ensure blinding of personnel, who would otherwise have been aware of treatment allocation from the operative notes.