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. 2017 Mar 28;2017(3):CD011343. doi: 10.1002/14651858.CD011343.pub2

Comparison 2. Pharmacological treatments for primary sclerosing cholangitis: stratified by ursodeoxycholic acid dose.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Mortality at maximal follow‐up 6   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.1 Colchicine vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.2 Penicillamine vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.3 Steroids vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.4 Ursodeoxycholic acid (high) vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.5 Ursodeoxycholic acid (moderate) vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
1.6 Vancomycin vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2 Serious adverse events proportion 3   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
2.1 Infliximab vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.2 Steroids vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.3 Vancomycin vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Serious adverse events number 4   rate ratio (Fixed, 95% CI) Totals not selected
3.1 Infliximab vs placebo 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
3.2 Penicillamine vs placebo 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
3.3 Steroids vs placebo 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
3.4 Ursodeoxycholic acid (high) vs ursodeoxycholic acid (moderate) 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
3.5 Ursodeoxycholic acid (high) vs ursodeoxycholic acid (low) 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
3.6 Ursodeoxycholic acid (moderate) vs ursodeoxycholic acid (low) 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Adverse events proportion 3   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
4.1 Steroids vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 Ursodeoxycholic acid (moderate) vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.3 Vancomycin vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Adverse events number 6   rate ratio (Fixed, 95% CI) Totals not selected
5.1 Cyclosporin vs placebo 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 Penicillamine vs placebo 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.3 Steroids vs placebo 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.4 Ursodeoxycholic acid (high) vs ursodeoxycholic acid (low) 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.5 Ursodeoxycholic acid (high) vs ursodeoxycholic acid (moderate) 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.6 Ursodeoxycholic acid (low) plus metronidazole vs ursodeoxycholic acid (low) 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.7 Ursodeoxycholic acid (moderate) vs ursodeoxycholic acid (low) 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.8 Vancomycin vs metronidazole 1   rate ratio (Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Quality of life 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
6.1 Ursodeoxycholic acid (moderate) vs placebo 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Liver transplantation 8   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
7.1 Colchicine vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 Penicillamine vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.3 Steroids vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.4 Ursodeoxycholic acid (high) vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.5 Ursodeoxycholic acid (moderate) vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.6 Vancomycin vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.7 Ursodeoxycholic acid (moderate) vs ursodeoxycholic acid (low) 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.8 Ursodeoxycholic acid (high) vs ursodeoxycholic acid (low) 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.9 Ursodeoxycholic acid (high) vs ursodeoxycholic acid (moderate) 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.10 Ursodeoxycholic acid (low) plus metronidazole vs ursodeoxycholic acid (low) 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Cholangiocarcinoma 4   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
8.1 Cyclosporin vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 Ursodeoxycholic acid (high) vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.3 Ursodeoxycholic acid (moderate) vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.4 Vancomycin vs placebo 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]