Neuberger 1985.

Methods	Randomised clinical trial.
Participants	Country: multicentric; international. Number randomised: 189. Post‐randomisation dropouts: not stated. Revised sample size: 189. Mean age: not stated. Females: 174 (92.1%). Symptomatic participants: 172 (91%). AMA positive: 163 (86.2%). Responders: not stated. Mean follow‐up period (for all groups): not stated. Inclusion criteria Symptom status: symptomatic and asymptomatic participants. AMA status: AMA‐positive and AMA‐negative participants. Response status: not stated. Exclusion criteria Taking azathioprine in the previous 6 months.
Interventions	Participants were randomly assigned to 2 groups. Group 1: D‐penicillamine (n = 98). Further details: D‐penicillamine: 1200 mg/day; duration: not stated. Group 2: placebo (n = 91).
Outcomes	Mortality, liver transplantation.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: information not available.
Allocation concealment (selection bias)	Low risk	Quote: "Opaque sealed envelopes" (author's reply).
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "Double blind trial, identical appearing placebo" (author's reply).
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "Assessors were blinded, identical placebo" (author's reply).
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Comment: information not available.
Selective reporting (reporting bias)	High risk	Comment: adverse events not reported.
For‐profit bias	Unclear risk	Quote: "Not pharmaceutical funding" (author's reply).
Other bias	Low risk	Comment: no other source of bias.