(please circle)	Source (page no. in report)
Type of study Can the study be described as randomized or quasi‐randomized, i.e. method of allocation is known but study is not considered strictly randomized?	Yes, Unclear, No
Participants 1. Were participants adults (≥ 16 years) in ICUs? 2. Did they have severe sepsis or septic shock (study authors' definitions)?	Yes, Unclear, No   Yes, Unclear, No
Interventions 1. HVHF0r HVHDF (> 35 mL/kg/h) vs some form of RRT OR 2. HVHF or HVHDF(> 35 mL/kg/h) vs no similar dialysis therapy	Yes, Unclear, No   Yes, Unclear, No
Outcomes: Did the study report any one of: 1. Mortality rates, ICU or hospital with deaths reported at 7, 28 or 30 days	Yes, Unclear, No
Conclusion: If study to be ‘included’ or ‘excluded & listed in excluded table’, record below the information to be inserted into tables. If included, continue to page 2. Included                         Excluded and should be listed in the excluded table Excluded and should NOT be listed in the excluded table More information needed before inclusion decision (specify):                                                        Record for tables: