Cole 2001.
| Methods | Country: Australia Setting: tertiary‐centre ICU Time frame: unclear Cross‐over RCT Intention‐to‐treat analysis: yes Follow‐up period: 2 days Lost to follow‐up: none |
|
| Participants | No. of participants randomized: 11 No. of participants analysed: 11 Mean age: 63.1 Male, no. (%): 8/11 (73) Inclusion criteria Septic shock (criteria of bone) Established ARF secondary to septic shock (with oliguria or anuria) Established need for RRT Recognized source of sepsis that had been treated with antibiotics and surgical drainage of source if necessary Exclusion criteria ESRD AIDS Life expectancy < 6 months Withdrawal of therapy possible |
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| Interventions |
Treatment intervention HVHF 8‐Hour session Filter: 1.6 m2 AN 69 Blood flow: 300 mL/min; ultrafiltrate flow: 100 mL/min Lactate buffered replacement fluid: one‐third delivered pre‐filter, two‐thirds post‐filter Control intervention CVVH 8‐Hour session Filter: 1.2 m2 AN 69 polyacrylonitrile Blood flow: 200 mL/min; ultrafiltrate flow: 1 L/h Lactate buffered replacement fluid delivered pre‐filter MAP to be maintained at > 70 mmHg throughout |
|
| Outcomes | Mean arterial pressure and norepinephrine dose | |
| Notes | Funding source: Austin & Repatriation Medical Centre Anaesthesia and Intensive Care Trust Fund and Hospal Pty Ltd No conflicts of interest declared |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Random sequence generation by computer programme |
| Allocation concealment (selection bias) | Low risk | Sealed opaque envelopes |
| Blinding of participants and personnel (performance bias) All outcomes | Low risk | Not possible to blind personnel to allocated treatment, although considered to be at low risk |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not stated as for whom or how outcome assessment was made |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing outcome data |
| Selective reporting (reporting bias) | Low risk | Protocol available and predefined outcomes reported |
| Other bias | Low risk | Appears to be free of other sources of bias |